Learn more about our FREE COVID-19 Patient Support Program for chronic illness patients and their loved ones.

An illustration of a coronavirus test tube surrounded by coronavirus germs.
Credit: Creative-Touch/iStock

Receiving news that someone you’ve been in close contact with has tested positive for COVID-19 can be extremely stressful. That may be even more worrisome if you’re immunocompromised, even if you’re fully vaccinated. Whether you have kids heading to school every day or your vaccinated partner has experienced a breakthrough case of the coronavirus, there’s some possibility that someone you live with could contract COVID-19.

However, if you follow a few key steps, you can lower your chances of getting infected yourself or needing hospitalization if you’re immunocompromised. Of course, the level of immunosuppression can vary greatly from one individual to another, so it’s important to speak to your doctor right away for specific guidance if someone you live with tests positive.

“Immunocompromised individuals are a large and diverse group of individuals, who are not all equally at risk of contracting COVID-19 or developing severe disease,” says Sydney Ramirez, MD, PhD, an infectious disease doctor and researcher at the University of California San Diego and La Jolla Institute for Immunology.

“They will also respond differently to vaccination and therapeutics,” continues Dr. Ramirez. “The specific underlying medical conditions that an individual has and the medications that they receive for those conditions or for other conditions will play a role in their ability to mount a protective or durable immune response to COVID-19 vaccination or infection.”

Here are some general steps to follow to help keep yourself and others in your household safe.

Separate yourself from the infected individual

It can be difficult when you live together, but do your best to separate yourself from the person in your home who is positive for COVID-19. If possible, that means staying six feet apart and using a different bathroom and bedroom, per the U.S. Centers for Disease Control and Prevention (CDC). It’s also a good idea to increase ventilation in your home — which helps to remove respiratory droplets from the air — by opening the windows.

Wear a mask at home

“Even if you’ve been vaccinated, including with a third dose of the COVID-19 vaccine, you may still be susceptible to the infection, so it would be important to try to separate if possible,” says Abinash Virk, MD, a consultant in the Division of Infectious Diseases at the Mayo Clinic. “I would also wear a mask at home so at least you can limit the likelihood of getting it. Perhaps the infected person can also be masked, particularly if you can’t separate.”

Get tested three to five days after exposure

People who are fully vaccinated don’t need to quarantine after contact with someone who had COVID-19 unless they have symptoms (though they should get tested three to five days after exposure, even if they don’t have symptoms), per the CDC. They should also wear a mask indoors in public for 14 days after exposure or until they receive a negative test.

Be prepared to quarantine

However, depending on your level of immunosuppression and risk, your doctor may have specific quarantine advice for you. If you do decide to quarantine as a precaution or end up getting symptoms (which would require you to quarantine), you should keep your loved ones informed about your situation so they can be ready to provide help as needed.

“Given that immunocompromised individuals can be at higher risk for severe COVID-19 and may not respond as well to COVID-19 vaccines, depending on their underlying level and type of immunocompromise, it is important that they have a support system checking in on them to make sure that they are doing well and have all of the necessary supplies and resources they will need for their isolation period,” says Dr. Ramirez.

In terms of keeping distance from the infected individual you live with, if they tested positive for COVID-19 and had symptoms, the CDC says they can be around others if it’s been:

  • 10 days since symptoms first appeared and
  • 24 hours with no fever without the use of fever-reducing medications and
  • Other symptoms of COVID-19 are improving (note: loss of taste and smell may continue for weeks or months after recovery and don’t need to delay the end of isolation)

If they tested positive but never developed symptoms, they can be around others after 10 days have passed since their positive viral test for COVID-19.

That said, if your loved one is also immunocompromised, your local public health care system or provider may recommend a longer isolation period.

“For immunocompromised individuals, the isolation period is dependent upon the level of immune compromise and disease severity if they develop COVID-19,” says Dr. Ramirez. “A longer, up to 20-day period of isolation from symptom onset, rather than the standard 10-day isolation period, has been recommended for individuals with severe to profound immunocompromise or those who have suffered from more severe COVID-19.”

In these cases, a doctor may use testing to help determine when your loved one can end isolation.

When to Get Tested

Even if you’ve been fully vaccinated and have no symptoms of COVID-19, you should get tested three to five days after your last exposure to the infected individual, per the CDC.

“If an immunocompromised person is a household contact of an individual who tests positive for COVID-19, they should closely monitor for the development of any signs or symptoms of COVID-19 and get tested as soon as possible — but within a few days — after the start of symptoms,” says Dr. Ramirez. “If they do not have symptoms, then they should get tested about 3 to 5 days after their last contact with the person who tested positive.”

Your doctor may recommend additional testing prior to ending isolation in both instances.

“It would be a good idea to get tested again another three to five days after your first test,” says Dr. Virk. “We know most people end up having symptoms within a week to 10 days after exposure.”

COVID-19 Symptoms to Look For

A wide range of symptoms have been associated with COVID-19 since the disease first emerged. Currently, the CDC lists the following as some COVID-19 symptoms:

  • Fever or chills
  • Cough
  • Shortness of breath or difficulty breathing
  • Fatigue
  • Muscle or body aches
  • Headache
  • New loss of taste or smell
  • Sore throat
  • Congestion or runny nose
  • Nausea or vomiting
  • Diarrhea

These do not list all potential symptoms, which may appear two to 14 days after exposure to the virus. However, even with the Delta variant circulating throughout the United States, symptoms haven’t changed drastically since the beginning of the pandemic.

“Generally, symptoms have been similar with Delta variant versus other variants,” says Dr. Ramirez. “Fever, cough, loss of smell or taste, shortness of breath, fatigue and malaise are still common symptoms. Headache, runny nose, sinus pressure, sore throat, body aches, nausea and diarrhea are also frequently reported.”

However, loss of smell and taste may be less common with the Delta variant. “Patients with Delta seem to not have as much loss of smell and taste as patients with the older strains did,” says Dr. Virk.

Symptoms may be milder if you’re vaccinated and get COVID-19 (a breakthrough infection).

“The majority of individuals who have experienced breakthrough infections have had milder and shorter-lived symptoms than unvaccinated individuals who have contracted COVID-19,” says Dr. Ramirez. “However, some individuals who are immunocompromised are unable to or did not form adequate protective immunity in response to vaccination and may have more severe COVID-19 regardless of their vaccination status.”

When Should You Consider Monoclonal Antibodies?

In August, the U.S. Food & Drug Administration authorized REGEN-COV — a monoclonal antibody treatment — to be used to prevent COVID-19 after exposure to an infected person in adults and children (age 12 and older, who weigh at least 88 pounds) who are at high risk for progression to severe COVID-19, including hospitalization or death. Before that, the treatment had already been approved to treat COVID-19 in high-risk individuals.

“As soon as you know you’ve had exposure to COVID-19 through a close contact, contact your health care facility right away and tell them that you’ve just been exposed,” says Dr. Virk. “Ask them what your options are for getting monoclonal antibodies to cut down your risk of getting a full-blown infection. Earlier is better for monoclonal antibodies.”

Monoclonal antibodies are lab-made proteins that mimic the immune system’s ability to ward off viruses like SARS-CoV-2, per the FDA. Monoclonal antibodies may stop the virus from sticking to your cells and help neutralize it — meaning they stop it from replicating and causing infection.

“Immunocompromised individuals should be considered for monoclonal antibody therapy when diagnosed with mild to moderate COVID-19, especially early after the diagnosis, if there are no contraindications to treatment,” says Dr. Ramirez.

REGEN-COV is contraindicated in people who have had previous severe hypersensitivity reactions, including anaphylaxis, to REGEN-COV, per Regeneron.

The Importance of the COVID-19 Vaccine

Most importantly, you should get fully vaccinated (including with the third dose of the COVID-19 vaccine, when applicable) to prevent contracting COVID-19 before you’re exposed to it. So far, studies show that vaccinated people are eight times less likely to be infected with COVID-19 and 25 times less likely to experience hospitalization or death, per the CDC.

And although data presented at a CDC Advisory Committee on Immunization Practices showed that immunocompromised patients represent 44 percent of hospitalized COVID-19 breakthrough cases (even though they only make up 2.7 percent of the population), hospitalization for breakthrough infection is still very rare to begin with.

It’s also important to speak to your loved ones, particularly those you live with or see regularly, about getting the vaccine.

“Household members and other close contacts of immunocompromised individuals should also be fully vaccinated, unless contraindicated, to protect both themselves and others — including their immunocompromised loved ones,” says Dr. Ramirez.

Get Free Coronavirus Support for Chronic Illness Patients

Join the Global Healthy Living Foundation’s free COVID-19 Support Program for chronic illness patients and their families. We will be providing updated information, community support, and other resources tailored specifically to your health and safety.

Caring for Someone Sick at Home. COVID-19. U.S. Centers for Disease Control and Prevention. July 2, 2021. https://www.cdc.gov/coronavirus/2019-ncov/if-you-are-sick/care-for-someone.html.

COVID-19 Frequently Asked Questions. U.S. Food & Drug Administration. September 13, 2021. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-frequently-asked-questions.

Data and clinical considerations for additional doses in immunocompromised people. U.S. Centers for Disease Control and Prevention. July 22, 2021. https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-07/07-COVID-Oliver-508.pdf.

Fact Sheet for Health Care Providers: Emergency Use Authorization (EUA) of REGEN-COV™ (casirivimab and imdevimab). Regeneron. September 2021. https://www.regeneron.com/downloads/treatment-covid19-eua-fact-sheet-for-hcp.pdf.

FDA authorizes REGEN-COV monoclonal antibody therapy for post-exposure prophylaxis (prevention) for COVID-19. U.S. Food & Drug Administration. August 10, 2021. https://www.fda.gov/drugs/drug-safety-and-availability/fda-authorizes-regen-cov-monoclonal-antibody-therapy-post-exposure-prophylaxis-prevention-covid-19.

Interview with Abinash Virk, MD, a consultant in the Division of Infectious Diseases at Mayo Clinic

Interview with Sydney Ramirez, MD, PhD, an infectious disease doctor and researcher at the University of California San Diego and La Jolla Institute for Immunology

Quarantine and Isolation. COVID-19. U.S. Centers for Disease Control and Prevention. July 29, 2021. https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html.

Symptoms of COVID-19. COVID-19. U.S. Centers for Disease Control and Prevention. February 22, 2021. https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html.

The Possibility of COVID-19 After Vaccination: Breakthrough Infections. COVID-19. U.S. Centers for Disease Control and Prevention. September 7, 2021. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/effectiveness/why-measure-effectiveness/breakthrough-cases.html.

  • Was This Helpful?