Methotrexate Education


  • First line of defense against several types of arthritis.
  • Least expensive version available.
  • No injection required.

Methotrexate in a pill form is considered a first-line treatment for rheumatoid arthritis (RA), psoriatic arthritis (PsA), and spondyloarthropathy. THe side effects include nausea and stomach inflammation, which many can find manageable. Taking a pill means no injection is required, which can be a source of concern for some patients. The pill version of methotrexate is also less expensive than its inject-able counterpart.


  • Prefilled and ready to use.
  • Auto-injector is easier to manage.
  • Less painful than the regular injection.

This is the newest of the three methods. The key difference between this and the reusable injection is that for a single-use injection, the patient does not need to refill the syringe on his or her own. This makes for a patient-friendly, patient-beneficial delivery. The injection can be administered without the need for measuring and handling the needle. This method is also reported to be less painful than traditional injections.


  • Equally effective if administered intramuscularly or subcutaneously.
  • Side effects are more manageable than the pill.
  • Slightly better absorption.

This injectable form of methotrexate is also taken once a week in a similar fashion to the pill. It is equally effective whether it is injected directly into the muscle or directly under the skin. The injection has also been associate with fewer side effects than the oral version. It has been shown in studies that the injection is slightly more effective than the oral version.