Two studies highlighted reasons why rheumatoid arthritis patients are noncompliant with their medications: 1) patients who have positive expectations about the course of their disease are much more likely to adhere to their treatment than those who feel less autonomous and become passive because of their joint pain; and 2) patient anxiety on starting methotrexate therapy predicts non-response to treatment at six months, and this might partly be explained by poor adherence. These new insights should be used to inform strategies designed to improve treatment adherence that in turn will optimize treatment outcomes and reduce healthcare costs.


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