An Italian study found that flares reported by RA patients in remission were associated with significantly greater risk of structural damage at two years, while flares identified by physicians during regular three-month office visits were not significant predictors of radiographic progression. Physician-detected  flares “might underestimate disease activity over time,” according to the researchers, who noted that most flares happen between physician visits. This study further supports the importance of patient reported outcomes to fully assess RA disease activity.


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