A Spanish study found that lupus patients given prednisone in medium dosages of 7.5 to 30 mg/day during their first month of treatment had an eight-fold higher likelihood of continuing on dosages above 7.5 mg/day throughout the first year compared with patients not on prednisone. The odds of staying on dosages above 7.5 mg/day were even greater for those starting treatment on high dosages above 30 mg/day. The researchers wrote that while glucocorticoids are one of the main therapies for lupus, “despite their proven efficacy, oral glucocorticoids are important predictors of irreversible damage in lupus.”

 

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