Arthritis can arise six to 12 months after being infected with Lyme disease, and knee involvement is nearly universal with late-onset Lyme arthritis. However, until now there were no documented cases of Lyme disease-related prosthetic joint infection. The 67-year-old patient’s symptoms resolved with antimicrobial therapy, highlighting the importance of early, fast diagnosis and adequate antimicrobial treatment. The patient had undergone a joint arthroplasty of his left knee in 2014 for degenerative arthritis prior to contracting Lyme disease.

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